发布时间：2017-07-25 09:59:04

SHP099产品描述：SHP099 is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM.IC50 & Target: IC50: 70 nM (SHP2)[1] In Vitro: The X-ray co-crystal for SHP099 with SHP2 reveals a new interaction with the basic amine and the Phe113 backbone carbonyl. SHP099 shows inhibition of c.........【阅读全文】

发布时间：2017-07-24 15:22:36

Brevianamide F产品描述：Brevianamide F , also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.Brevianamide F possess interesting breast cancer resistance protein inhibitory activity.[1] brevianamide F once used as aromatic substrate. [2] 公司介绍：Me.........【阅读全文】

发布时间：2017-07-24 15:21:25

NKL 22产品描述：NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM NKL 22 increase frataxin protein concentrationsNKL 22 inhibitors increase FXN mRNA in FRDA lymphocytes.HDAC inhibitors act directly on FXN. [1] 公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于.........【阅读全文】

发布时间：2017-07-24 15:20:35

BH3I-1产品描述：BH3I-1 is an inhibitor of Bcl-xL with IC 50 of 293.95 μM. BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL, BH3I-1 can induce cell death. BH3I-1 is a bak activator target: Bcl-xLIC 50: 293.95 uM(1) BH3I-1 can exerted an antineoplastic effect in thyroid carcinoma cells .........【阅读全文】

发布时间：2017-07-24 15:19:44

FPTQ产品描述：FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. Inhibit [3H] FTIDC target: mGluR1IC 50: 6 nM [1]In vivo: FPTQ exhibited dose-dependent and plasma concentration-dependent receptor occupancy in the cerebellum and striatum. Compound A in.........【阅读全文】