发布时间：2017-07-25 10:08:57

AZD0865产品描述：AZD0865 inhibits gastric H+,K+-ATPase by K+-competitive binding. (IC50: 1.0 ± 0.2 μM)It is a acid-suppressing agents with rapid onset of action and potent acid inhibition. In vitro: AZD0865 can inhibit the final step in acid secretion. AZD0865 reduced porcine renal Na+,K+-ATPas.........【阅读全文】

发布时间：2017-07-25 10:07:35

MLi-2产品描述:MLi-2是高效选择的，具有口服活性，可渗透大脑的LRRK2抑制剂。IC50值为0.76 nM。公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子.........【阅读全文】

发布时间：2017-07-25 10:06:20

FCCP产品描述：FCCP is a mitochondrial uncoupling agent, used in cancer research. In Vitro: FCCP (5 μM) results in a concentration-dependent decrease in Aβ and APPsβ production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concent.........【阅读全文】

发布时间：2017-07-25 10:05:04

PHCCC产品描述：PHCCC is a Group I metabotropic glutamate receptor antagonist with EC50 of 6 uM and a positive allosteric modulator of mGluR4. Also as a potent to antagonism for mGluR2 and mGluR8.target: a Group I metabotropic glutamate receptor antagonistEC 50: 6 uMIn vitro: PHCCC potentiates L-A.........【阅读全文】

发布时间：2017-07-25 10:04:38

GNF-6231产品描述：GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration..........【阅读全文】