发布时间：2017-07-21 09:10:12

Ibrutinib-biotin产品描述：Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an IC50 of 0.755-1.02 nM for BTK.IC50 & Target: IC50: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.........【阅读全文】

发布时间：2017-07-21 09:09:10

M2I-1产品描述：M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. It can also inhibited the.........【阅读全文】

发布时间：2017-07-21 09:08:42

GSK583产品描述：GSK583 is a highly potent and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM.IC50 & Target: IC50: 5 nM (RIP2K)[1] In Vitro: GSK583 (1 μM) exhibits excellent selectivity in a panel of 300 kinases, including p38α and VEGFR2. GSK583 potently and dose dependently inhibits MDP-s.........【阅读全文】

发布时间：2017-07-21 09:07:56

AC260584产品描述：AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC50 of 7.6.IC50 & Target: pEC50: 7.6 (M1)[1] In Vitro: AC260584 is found to be a potent (pEC50=7.6-7.7) and efficacious (90-98% of carbachol) muscarinic M1 receptor agonist. AC260584 shows functional selectivity for.........【阅读全文】

发布时间：2017-07-21 09:07:27

Nutlin (3a)产品描述：Nutlin (3a) is a murine double minute (MDM2) antagonist that inhibits MDM2-p53 interactions and stabilizes the p53 protein, thereby inducing cell cycle arrest and apoptosis.IC50 & Target: MDM2-p53[1] In Vitro: Nutlin-3a is a therapeutic which inhibits MDM2, activates wild-type .........【阅读全文】