发布时间：2017-07-21 09:06:59

SZL P1-41产品描述：SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes.target: Skp2In vitro: SZL P1-41 also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as wel.........【阅读全文】

发布时间：2017-07-21 09:06:01

Madrasin产品描述：Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear.........【阅读全文】

发布时间：2017-07-21 09:05:00

EPZ015866产品描述：EPZ015866 (GSK591) is a potent selective inhibitor of the arginine methyltransferase PRMT5. It maintained excellent selectivity against other PMT enzymes observed with EPZ015666 [1].IC50:61 nM-904 nM in Maver-1 cells [2]target: PRMT5in vitro: A375 cells treated for 18 h with 1 .........【阅读全文】

发布时间：2017-07-21 09:02:28

DREADD agonist 21产品描述：DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist(EC50=1.7 nM). IC50 & Target: EC50: 1.7 nM (hM3Dq)[1]Ki: 6 nM (H1 histamine receptor), 66 nM (5HT2A serotonin receptor 5HT2A), 170 nM (5HT2C serotonin receptor), 280 nM (α1A adrener.........【阅读全文】

发布时间：2017-07-21 08:58:38

IQ-1S (free acid)产品描述：IQ-1S (free acid) is an inhibitor of JNK kinases, with a preference for JNK3. Kd values for IQ-1S binding to JNK 1, 2 and 3 binding are 390, 360 and 87 nM, respectively. [1] Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates coll.........【阅读全文】