产品描述:F16 is a small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines.
1, F16 induced cell cycle arrest in sensitive mouse tumor and human cancer cell lines.
2, Prolonged incubation with 3 uM F16 resulted in increased cell death of F16-sensitive cells but not of F16-resistant ones.
3, F16 caused apoptosis in A6 cells.
4, F16 caused a dramatic decrease in the number of cells in S phase and an increase in the percentage of cells in G1 phase.
5, F16 is capable of inhibiting oxidative phosphorylation and inducing mitochondrial transmembrane depolarization.
公司介绍:MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库,总部位于美国新泽西,分别在瑞典和上海设有欧洲区子公司和亚洲区总代理,营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商, 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域,PI3K、MAPK等近千个细分靶点,超过4000个活性小分子化合物现货,以及GPCR、API、离子通道等超过20种不同类型的化合物库,同时提供从毫克到千克的专业定制合成服务。
MCE 对每批产品都进行严格的LCMS和NMR检验,其产品已被全球近万名客户广泛使用并发表大量文章、专利;
MCE 定期增加各领域热门抑制剂、激动剂,不断扩增已有化合物库,以满足最新的科研需求;
数千种产品在上海有充足备货,24-48小时内送达客户;
大量产品提供免费试用装;
已为全球多个知名企业、院校构建各种定制型化合物库。
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