产品描述:BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.
target: VEGFR
IC 50: 37 nmol/L
In vitro: BAW2881 block VEGF-A-induce proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) and lymphatic endothelial cells (LECs)
In vivo: In a transgenic mouse model of psoriasis, NVP-BAW2881 reduce the number of blood and lymphatic vessels and infiltrating leukocytes in the skin, and normalize the epidermal architecture. NVP-BAW2881 also display strong anti-inflammatory effects in models of acute inflammation. Pretreatment with topical NVP-BAW2881 significantly inhibited VEGF-A-induced vascular permeability in the skin of pigs and mice.
NVP-BAW2881 can dissolve in polyethylene glycol-200 and orally administered to mice in a dose of 25 mg/kg/day in 10 ml/kg.
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