产品描述:SQ22536 is an effective
adenylate cyclase (
AC) inhibitor.
IC50 & Target: adenylate cyclase (AC)
[1] In Vitro: SQ22536 (SQ22,536) effectively inhibits the effect of forskolin with respective IC
50 values of 5 μM.Preincubation with graded concentrations of SQ22536 reveals that both SQ22536 effectively inhibits PACAP-induced reporter gene activation with approximate IC
50 value of 5 μM. SQ22536 more potently inhibits forskolin-induced Elk activation (IC
50=10 μM) than 8-Br-cAMP-induced Elk activation (IC
50=170 μM). Most notably, there are substantial differences in the reported potencies of SQ22536 to inhibit the activities of recombinant AC5 and AC6, with respective IC
50 values of 2 μM and 360 μM. At a greater concentration (500 μM), SQ22536 significantly inhibits neurite elongation due to either forskolin or 8-Br-cAMP
[1].
公司介绍:MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库,总部位于美国新泽西,分别在瑞典和上海设有欧洲区子公司和亚洲区总代理,营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商, 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域,PI3K、MAPK等近千个细分靶点,超过4000个活性小分子化合物现货,以及GPCR、API、离子通道等超过20种不同类型的化合物库,同时提供从毫克到千克的专业定制合成服务。
MCE 对每批产品都进行严格的LCMS和NMR检验,其产品已被全球近万名客户广泛使用并发表大量文章、专利;
MCE 定期增加各领域热门抑制剂、激动剂,不断扩增已有化合物库,以满足最新的科研需求;
数千种产品在上海有充足备货,24-48小时内送达客户;
大量产品提供免费试用装;
已为全球多个知名企业、院校构建各种定制型化合物库。
产品链接:
阅读(129) | 评论(0) | 转发(0) |