产品描述：Calcitriol is the most active metabolite of vitamin D. Many of the effects of Calcitriol are mediated by its interaction with the
vitamin D receptor (
VDR).
IC50 & Target: Vitamin D receptor (VDR)
[1] In Vitro: In parathyroid cells, Calcitriol acts through the vitamin D receptor (VDR) to inhibit PTH mRNA expression. In normal dog parathyroid glands, culture with Calcitriol (10
-10 to 10
-7 M) for 24 h produces a dose-dependent inhibitory effect on the progression of cells into the cell cycle and into apoptosis. Even a low Calcitriol concentration (10
-11 and 10
-10 M) reduces the progression to the S phase and to apoptosis. As the Calcitriol concentration is increased from 10
-9 to 10
-8M, a further suppression of cells entering the cell cycle and apoptosis is observed. Moreover, a significant correlation (r=0.95, P<0.01) is observed at the different Calcitriol concentrations between the
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